Riluzole (generic name) is drug therapy used to treat ALS. Riluzole is designed to be taken by mouth as directed, usually every 12 hours, at the same times each day, and is best taken on an empty stomach (one hour before a meal, or two hours after a meal). Despite what is often read online, there is no increased benefit from higher doses. Higher doses do increase the risk of side effects. Side effects include: nausea, loss of appetite, dizziness, vomiting, drowsiness, stomach pain, weakness, diarrhea, constipation and numbness around the mouth.