ALSforums
Old 02-14-2006, 10:24 AM   #1 (permalink)
Senior Member
rcharlton's Avatar
Join Date: 2005
City: Toronto
State: Ontario
Country: CA
Diagnosed: 11/2005
Posts: 616
rcharlton is on a distinguished road
Default Theory: Toxin in gut causes ALS

Here's is an interesting, though still unproven theory. I find it interesting as I underwent colon hydrotherapy treatment over the summer - and during that period and for months after I had no noticeable progression of my symptoms. Since the late fall, a few months after I started treatment, I have had noticeable progression. Now of course this is just anecdotal, and my ALS may just have temporarily plateaued - but I may start up some treatments to see if it makes a difference.

Hypothesis: A motor neuron toxin produced by
a clostridial species residing in gut causes ALS


Summary We hypothesize that a yet-to-be-identified motor neuron toxin produced by a clostridial species causes sporadic amyotrophic lateral sclerosis (ALS) in susceptible individuals. This clostridial species would reside undetected in the gut and chronically produce a toxin that targets the motor system, like the tetanus and botulinum toxins. After
gaining access to the lower motor neuron, the toxin would be transported back to the cell body, as occurs with the tetanus toxin, and destroy the lower motor neuron the essential feature of ALS. Again like the tetanus toxin, some of the toxin would cross to neighboring cells and to the upper motor neuron and similarly destroy these motor neurons.
Weakness would relentlessly progress until not enough motor neurons remained to sustain life. If this hypothesis were correct, treatment with appropriate antibiotics or antitoxins might slow or halt progression of disease, and immunization might prevent disease.
c 2004 Elsevier Ltd. All rights reserved.

W.T. Longstreth Jr.a,b,c,*, J.S. Meschked, S.K. Davidsone, L.M. Smoote,
J.C. Smoote, T.D. Koepsellb,c,f

a Department of Neurology, School of Medicine, University of Washington, Seattle, Washington, USA

b Department of Medicine, School of Medicine, University of Washington, Seattle, Washington, USA

c Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA

d Department of Environmental Health, School of Public Health and Community Medicine, University of
Washington, Seattle, Washington, USA

e Department of Civil and Environmental Engineering, College of Engineering, University of Washington, Seattle, Washington, USA

f Department of Health Services, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA

Received 19 July 2004; accepted 22 July 2004

rcharlton is offline  
Closed Thread

Tags
als, back, cell, health, life, medicine, mental health, neurology, progression, sporadic, symptoms, toxins, treatment, treatments



Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools Search this Thread
Search this Thread:

Advanced Search


Similar Threads for: Theory: Toxin in gut causes ALS
Thread Thread Starter Forum Replies Last Post
Hawking's movie The Theory Of Everything guguy Other 3 08-30-2014 11:42 AM
The Theory of Everything, Stephen Hawking biopic canmark Stories of Hope 0 08-06-2014 08:29 PM
Novel theory about ALS cause Janc General Discussion About ALS/MND 8 07-19-2014 08:14 AM
Toxin from Brain Cells Triggers Neuron Loss in Human ALS Model fillemvs ALS Research News 3 02-07-2014 03:49 PM
toxin and toxic pearshoot General Discussion About ALS/MND 3 01-22-2013 10:07 PM
Stephan Hawking on Big Bang Theory Miss Stories of Hope 11 04-06-2012 10:23 PM
Theory Chase_Corin Current Caregivers (CALS) 29 04-19-2011 07:25 PM
My personal trigger theory about lyme and ALS terrics About Lyme Disease 1 08-06-2010 12:34 PM
Interesting Theory - high activity levels and MND Just J General Discussion About ALS/MND 6 03-02-2010 02:37 PM

Go to the top of the page

    
   
   
   
   
  ALSforums - Get help and support with ALS/MND