BethU
Extremely helpful member
- Joined
- May 11, 2008
- Messages
- 2,646
- Reason
- PALS
- Diagnosis
- 05/2008
- Country
- US
- State
- California
- City
- Los Angeles
Hi ... I have no idea what I'm talking about on anything medical, but I found the following article on the Wiley InterScience website, quoting an article from the journal "Muscle & Nerve," Vol 36, Issue 3, pp 304-399, 12 Feb 2007.
I know that my neuros are right and I have ALS, but because of my double & blurred vision, I'm still poking around in Myasthenia Gravis websites. What interests me in the following article is that these doctors reversed muscle atrophy. I have never heard of that before. If they can reverse muscle atrophy in its rare appearance in MG, could it not be done in ALS?
It wouldn't reverse the ALS disease process, of course, but slowing or reversing atrophy would surely lead to a better quality of life.
Of course, I have no idea what "neurogenic muscle atrophy" is or if it is the same thing as ALS atrophy.
BethU
Case of the Month
Myasthenia gravis presenting with unusual neurogenic muscle atrophy
Miharu Samuraki, MD 1 *, Eisuke Furui, MD, PhD 1, Kiyonobu Komai, MD, PhD 1, Masaharu Takamori, MD, PhD 2, Masahito Yamada, MD, PhD 1
1Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1, Takaramachi, Kanazawa, Ishikawa 920-8640, Japan
2Neurological Center, Kanazawa-Nishi Hospital, Kanazawa, Japan
email: Miharu Samuraki ([email protected])
*Correspondence to Miharu Samuraki, Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1, Takaramachi, Kanazawa, Ishikawa 920-8640, Japan
Keywords
histochemical studies • muscle atrophy • myasthenia gravis • neurogenic changes • single-fiber EMG
Abstract
We report a patient with myasthenia gravis who had neurogenic muscle atrophy in association with external ophthalmoplegia and weakness of the upper limbs. Neurogenic changes in the limb muscles were found on needle electromyography and histological studies. Symptoms improved and atrophy of the limbs diminished after intravenous immunoglobulin and oral corticosteroid therapy. We concluded that functional interruption of the neuromuscular junction caused the neurogenic muscle atrophy and that this was relieved by appropriate therapy. Muscle Nerve, 2007
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Accepted: 4 January 2007[/I]
I know that my neuros are right and I have ALS, but because of my double & blurred vision, I'm still poking around in Myasthenia Gravis websites. What interests me in the following article is that these doctors reversed muscle atrophy. I have never heard of that before. If they can reverse muscle atrophy in its rare appearance in MG, could it not be done in ALS?
It wouldn't reverse the ALS disease process, of course, but slowing or reversing atrophy would surely lead to a better quality of life.
Of course, I have no idea what "neurogenic muscle atrophy" is or if it is the same thing as ALS atrophy.
BethU
Case of the Month
Myasthenia gravis presenting with unusual neurogenic muscle atrophy
Miharu Samuraki, MD 1 *, Eisuke Furui, MD, PhD 1, Kiyonobu Komai, MD, PhD 1, Masaharu Takamori, MD, PhD 2, Masahito Yamada, MD, PhD 1
1Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1, Takaramachi, Kanazawa, Ishikawa 920-8640, Japan
2Neurological Center, Kanazawa-Nishi Hospital, Kanazawa, Japan
email: Miharu Samuraki ([email protected])
*Correspondence to Miharu Samuraki, Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1, Takaramachi, Kanazawa, Ishikawa 920-8640, Japan
Keywords
histochemical studies • muscle atrophy • myasthenia gravis • neurogenic changes • single-fiber EMG
Abstract
We report a patient with myasthenia gravis who had neurogenic muscle atrophy in association with external ophthalmoplegia and weakness of the upper limbs. Neurogenic changes in the limb muscles were found on needle electromyography and histological studies. Symptoms improved and atrophy of the limbs diminished after intravenous immunoglobulin and oral corticosteroid therapy. We concluded that functional interruption of the neuromuscular junction caused the neurogenic muscle atrophy and that this was relieved by appropriate therapy. Muscle Nerve, 2007
--------------------------------------------------------------------------------
Accepted: 4 January 2007[/I]
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