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Question about mice with ALS?

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4rhl1981

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How do researchers induce ALS in mice if they don't know what causes ALS?
 

Marjorie R. Wilcox

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Probably they play tricks with the auto immune system or cut off nutrition fed to the muscles from the nerves somehow............because that's what ALS does, I understand.
 

JohnMc

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Don't know for sure, but I think the mouse studies are done on the familial form of ALS - they think they know which gene is related to this.
 

ZenArcher

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They use mice that have the SOD1 mutation related to familial ALS. It expresses the gene approximately 30 times more than humans. For more info Google G93A-SOD1.
 
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