- Mar 25, 2011
- Friend was DX
Our results clearly indicate that propofol can up-regulate Annexin A1 to inhibit the phosphorylation level of p38 and release of IL-1β, IL-6 and TNF-α, so as to inhibit inflammatory response. Carlos
These are only partial scientific papers.
The majority of these papers/abstracts can be found/read at ALS-TDI Forums under the Propofol thread.
Although, it might not be the definite cure for ALS/MND we PALS have been waiting for, but at least if it gets to stabilize the progression of the disease for some time, while more promising drugs are discovered, then Propofol is definitely worth to look at, isn't it?
Dear all, I am really strongly considering Propofol for my brother! Is there anyone that has actually been to Peurto Vallarta to receive it? Or anywhere for that matter. We are from the UK and happy to travel anywhere. Would love some information on the best combination and how much.
FightingAttorney10 Posted: Monday, July 22, 2013 8:33:09 PM
I received 400 mg of Propofol via IV sedation. I have experienced some increase in strength in right pectoral muscle, and did check FVC which has increased 15%. However, I am having to go to different location due to bait and switch tactics. Please be advised that these quotes change dramatically and all these doctors are preying on us. I will be getting more Propofol in another location, but $1500 can turn into much more and very quickly. I am a good negotiator as it is part of what I do for a living , but they still are preying on us. I will discuss by private email only.
It is not terminal until you are in the ground. Fight till you cannot fight anymore.
If anyone is interested in treatment in Mexico.
Thank you for your email.
Please see my Answers below and let me know if I can be of any further assistance.
1- We can schedule you to come as early as the first week of August, 2013.
2- As you already know, this is a rather recent approach, and it is done under the highest medical standards, Dr. Morales treats his patients depending on their current medical status to ensure the best outcome. Treatment is performed in our medical facilities and we have in our team anaestheaiologist, hematologist, vascular cardiologist and pheresis nurses.
3- The total cost is U.S. $2,000 per session, and includes all medical expenses related to the treatment.
4- Each session is performed PER DAY and we usually recommend no less than 4 sessions to have prolonged positive results.
5- We are currently in the selection process and are taking in potential candidates for treatment for the first half of August, if you would like to consider us for your treatment please let me know at your earliest convenience.
6- Dr. Estrada is an Anesthesiologist and Dr. Morales is an Hematologist will perform the treatment personally.
7- We ask 50% payment upon arrival and remaining balance should be covered upon completion of treatment.
Based on the reports from PALS who have tried Propofol, here's what we know so far about their effect on ALS symptoms:
1. They work and the improvements begin to occur within hours after anesthesia.
2. Low doses of propofol (less than 200 mg) are not very effective against ALS symptoms.
3. 800 mg of Propofol can result in major improvements.
4. 1200 mg of Propofol alone resulted in very major improvements (ceiling effect?).
5. Improvements can last up to 4 weeks or more.
6. Low dose (150 mg) can eliminate anxiety levels for about 24 hours (1 patient).
7. Propofol seem to be effective against both Limb-onset and Bulbar-onset ALS.
If you can think of anything else I may have missed, post it here and I'll revise the list.
EFFECT OF PROPOFOL ON AUTOPHAGY - MEDIATED STRESS RESPONSE IN MOTOR NEURON AFTER TRANSIENT SPINAL CORD ISCHEMIA IN RABBITS
Y. Watanabe1, M. Sakurai2, T. Kawamura1, K. Abe3
Anesthesiolosy, Cardiovascular Surgery, National Hospital Organization Sendai Medical
Center, Sendai, Neurology, Okayama University, Okayama, Japan
Objective: The mechanism of spinal cord injury has been thought to be related to the vulnerability of spinal motor neuron cells against ischemia. The aim of this study was to investigate whether propofol could protect against ischemic spinal cord damage by suppressing autophagic change.
Methods: We used a rabbit spinal cord ischemia model with use of a balloon catheter. In transient ischemia and treatment with vehicle group and treatment with propofol group, saline or propofol was administered intravenously 10 minutes before the induction of ischemia. Spinal cord was removed at 8 hours, and 1, 2, and 7 days after 15 minutes of transient ischemia. Cell damage was analyzed by counting the number of motor neurons and histological changes. Western blot analysis used for microtubule-associated protein light chain 3(LC3) andγ-aminobutyric-acid type-A (GABAA) -receptor-associated protein (GABARAP), temporal profiles of LC3 and GABARAP immunoreactivity were performed.
Results: In the Group I, about 85% of motor neurons were preserved until 2 days after reperfusion, but were serectively lost at 7 days. In contrast, in the Group P, motor neurons were presereved after 2 days. Western blot analysis and immunoreactivity for LC3 and GABARAP demonstrated that the induction of LC3 and GABARAP were slightly detectable in the sham group samples, which was then strongly enhanced at 8 hours, and was preserved until 2 days after reperfusion in the Group I. In the group P, LC3 and GABARAP were detectable but did not
Conclusions: Propofol eased the functional deficits and increased the number of motor neuons after ischemia. This study indicates that propofol may protect motor neurons from ischemic injury by suppressing augtophagic change. These results suggest that Propofol is a therapeutic agent in the treatment of ischemic spinal cord injury.