Pls?

[Brother Rock]

How long did you have symptoms before PLS was diagnosed? It is my understanding that it takes several years to diagnose? Sya, did he see an ENT already to be sure of their diagnosis? Swallow study and all that?

notme

Primary lateral sclerosis - Wikipedia, the free encyclopedia

Symptoms and progression

Onset of PLS usually occurs spontaneously after age 50 and progresses gradually over a number of years, or even decades. The disorder usually begins in the legs, but it may start in the tongue or the hands. Symptoms may include difficulty with balance, weakness and stiffness in the legs, and clumsiness. Other common symptoms are spasticity (involuntary muscle contraction due to the stretching of muscle. Muscle contraction is dependent on the velocity of the stretch) in the hands, feet, or legs, foot dragging, and speech and swallowing problems due to involvement of the facial muscles. Breathing may also become compromised in the later stages of the disease, causing those patients who develop ventilatory failure to require noninvasive ventilatory support. Hyperreflexia is another key feature of PLS as seen in patients presenting with the Babinski's sign. Some people present with emotional lability and bladder urgency, and occasionally people with PLS experience mild cognitive changes detectable on neuropsychological testing, particularly on measures of executive function.

PLS is not considered hereditary when onset is in adulthood; however, juvenile primary lateral sclerosis (JPLS) has been linked to a mutation in the ALS2 gene which encodes the cell-signalling protein alsin.

The issue of whether PLS exists as a different entity from ALS is not clear, as some patients initially diagnosed as having PLS ultimately develop lower motor neuron signs.

There are no specific tests for the diagnosis of PLS. Therefore, the diagnosis occurs as the result of eliminating other possible causes of the symptoms and by an extended observation period.

 

[AKmom]

Johnny, that is were humans have goofed up. They think God has brought these horrible disease on them, yet in the original design of creation, no disease was present. It was the free will of man/woman to choose their destiny and curse their off spring. So because of sin, we live in a dying world. But because of Gods love, we still have a choice to change our final destiny on where we end up. Hell will be much worse than what our bodies are going through right now. I for one, will cling to the Hope I have through God's provision of grace, which is Jesus his son.

 

[olly]

that is why,just as through one man sin entered into the world and death through sin,and thus death spread to all men because they all had sinned.............romans 5v12.

the blame is all on adam johnny.