NSAIDs-Prostaglandin Inhibitors

nightowl

Member
Joined
Aug 19, 2017
Messages
21
Reason
Loved one DX
Diagnosis
11/2016
Country
US
State
Texas
City
Houston
Good Evening,

I ended up researching due to my own problems that I encountered recently. Long story; short

There may be a correlation between NSAIDs and muscle atrophy.

Link Here:

This is a study from 2004 which analyzed the effects of prostaglandin inhibitors on muscles, studied on rats. They saw that muscles that sustained injuries while on COX2 inhibitors/Prostaglandin inhibitors had a delayed regenerative effect when compared to those that did not have these medications.

I dont propose anything, but it may be possible that long use of these specific medications can cause long term damage. A theory, i suppose.

How i got to this:

My father has ALS, been sick for 5 years plus. Sporadic ALS.

I recently suffered a bulging L5 disk injury while at work and was prescribed Meloxicam. From my knowledge this medication was just like a "Tylenol/Advil" so I didnt think much about it. I took it for 1 week completely and by the second week I started noticing weird muscle twitches all around my body. Obviously, from my personal experience I thought the worst.
Reasons for twitching: high caffeine, stress, anxiety, no sleep, dehydration, etc. I live with all of those on the daily.
The day i stopped taking it, twitches were constant and had very bad sleep then i developed more anxiety, muscle pain, over the next days i began to feel a burning sensation; neuropathy with pins and needles all around my body. Over the next days i have had less twitching, neuropathy still present and a feeling of soreness as if i had been working out a lot.

My research for these symptoms had led me to this area.

Im not the best at medicine but I do have 10+ years of experience/knowledge in the medical field.
 

Bestfriends14

Very helpful member
Forum Supporter
Joined
May 7, 2017
Messages
1,542
Reason
CALS
Diagnosis
05/2017
Country
CA
State
AB
City
CALGARY
I believe this speaks to musculoskeletal issues and not neurologic ones, such as ALS. ALS starts in the brain and is not a result of an injured muscle, so NSAIDS would have no correlation to the progression of ALS. Hope that gives you some relief.
 

lgelb

Moderator
Forum Supporter
Joined
Nov 5, 2009
Messages
11,358
Reason
Lost a loved one
Diagnosis
00/0000
Country
US
State
WA
City
Seattle
NSAIDs do have systemic effects and, for example, are especially dicey in older people, people with heart disease, and others at bleeding risk.

Meloxicam is an old drug with a ton of interactions. It should not have been written for an acute disk injury IMHO. I'm glad you went off it. Ask about PT for your spine.
 

Hal

New member
Joined
Mar 4, 2022
Messages
7
Reason
PALS
Diagnosis
09/2021
Country
US
State
MA
City
SOUTH HAMILTON
For what it's worth my mom had lupus but it was the years of being prescribed NSAIDS that eventually caused her death per the hospital Drs...
 

affected

Guru status reached
Joined
Apr 26, 2013
Messages
14,392
Reason
Lost a loved one
Diagnosis
05/2013
Country
OZ
State
AU
City
lala land
I never knew my husband to take any NSAIDS FWIW and he had aggressive Bulbar onset with FTD.
 
Top