Hi, I have just found this site and am very impressed with all the compassion and insightful thoughfulness so many of you show. It is comforting to know there are others that are so willing to impart their knowledge. I am 51 and am having so many similiar symptoms so many of you have mentioned. The muscle twitching for me started about a year ago in both my calves. I saw a neurologist at that time for that as well as severe vertigo, insomnia, not coping with stress at work, insomnia, and trouble with speech and word finding difficulties.I have not worked since that time. Was told these were menapausal symptoms. Not impressed. In Sept 05 started with speech slurring neck stiffness and base of skull tightness. Had 2 CT and MRI (brain) which was normal. At that time thought I may have MS. Symptoms seemed to subside, but started up again in Jan 06, difficulty talking, trouble swallowing, choking episodes , and left leg drag and severe cramping and spasms at night and upon waking. Twitching in both legs all day long. Saw the neurologist again a month ago. I have another MRI boooked on Tues. Skull base and C-spine. I am really distressed. Its the not nknowing for me that is the hard part. I also fell flat on my side getting out of our truck. Stepped out on the left leg and it just gave way, very scarry. What are anybodys thought. I know I have rambled on and on , sorry for that . I do realize from other posts that there is no clear diagnostic tool and many of you are in the same boat. Thanks for any info any of you can provide.