Jewels99
New member
- Joined
- Jun 3, 2008
- Messages
- 2
- Reason
- Learn about ALS
- Country
- US
- State
- Ut
- City
- SLC
Hello all! I'm new here and I'm in the process of being DXed. I want to thank you all for sharing so freely on here..for people new to the process, it brings great comfort as well as a wealth of knowledge.
My appointment with the MND/ALS Center at the U of U is over a month away. I can't believe how slow everything runs when it comes to ALS.
With it's course, you would like there would be some sense of urgency...
Anyway, I don't have many privilages here and can't really access anything, so I was wondering if some of you could elaborate alittle or enlighten me on some of these drugs...
It appears that 3 treatments, talampanel, tamoxifen and lithium have
encouraging data from small, pilot studies in people with ALS. But what of these others...and have any studies been initiated that use combinations of these drugs?
What's the hold up on the 3 listed above...if it shows promising results...lets get it going with everyone! Wouldn't 1000 of us be a strong enough study to show actual results?
I just feel so frustrated right now...
These are the drugs I found listed...
Ceftriaxone: Glutamate antagonisms (Increases EAAT2/GLT1 activity), antioxidant
ONO-2506 Prevents reactive astrocytosis; glutamate antagonism
Co-enzyme Q-10 Antioxidant; facilitates mitochondrial respiration
Memantine: N-methyl D-aspartate (NMDA) receptor antagonist
MCI-186: Antioxidant, facilitates mitochondrial respiration; anti-apoptotic
Diaphragm Pacing: Implantation of a minimally invasive diaphragm pacing system (DPS) with therapeutic electrostimulation may help maintain diaphragm function and slow or arrest the rate of respiratory decline in patients with amyotrophic lateral sclerosis.
Arimoclomo:l Heat shock protein inducer
Antisense Oligonucleotide: Decrease production of SOD1 protein. Trial for people with familial ALS
SOD1 secondary to mutations in the gene for superoxide dismutase 1.
Talampanal: a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)
receptor modulator (glutamate antagonist)
TRO19622: facilitates mitochondrial respiration; glutamate antagonist;
anti-apoptotic
R+ Pramipexole: Antioxidant
Arimoclomol – FALS Heat shock protein inducer; Trial for people with ALS
secondary to mutations in the gene for superoxide dismutase 1.
Lithium: Increased autophagy, anti-apoptotic, glutamate antagonist
Any and all info or comments would be greatly appreciated...
Thanks again for sharing so freely here...It has meant alot to me!
My appointment with the MND/ALS Center at the U of U is over a month away. I can't believe how slow everything runs when it comes to ALS.
With it's course, you would like there would be some sense of urgency...
Anyway, I don't have many privilages here and can't really access anything, so I was wondering if some of you could elaborate alittle or enlighten me on some of these drugs...
It appears that 3 treatments, talampanel, tamoxifen and lithium have
encouraging data from small, pilot studies in people with ALS. But what of these others...and have any studies been initiated that use combinations of these drugs?
What's the hold up on the 3 listed above...if it shows promising results...lets get it going with everyone! Wouldn't 1000 of us be a strong enough study to show actual results?
I just feel so frustrated right now...
These are the drugs I found listed...
Ceftriaxone: Glutamate antagonisms (Increases EAAT2/GLT1 activity), antioxidant
ONO-2506 Prevents reactive astrocytosis; glutamate antagonism
Co-enzyme Q-10 Antioxidant; facilitates mitochondrial respiration
Memantine: N-methyl D-aspartate (NMDA) receptor antagonist
MCI-186: Antioxidant, facilitates mitochondrial respiration; anti-apoptotic
Diaphragm Pacing: Implantation of a minimally invasive diaphragm pacing system (DPS) with therapeutic electrostimulation may help maintain diaphragm function and slow or arrest the rate of respiratory decline in patients with amyotrophic lateral sclerosis.
Arimoclomo:l Heat shock protein inducer
Antisense Oligonucleotide: Decrease production of SOD1 protein. Trial for people with familial ALS
SOD1 secondary to mutations in the gene for superoxide dismutase 1.
Talampanal: a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)
receptor modulator (glutamate antagonist)
TRO19622: facilitates mitochondrial respiration; glutamate antagonist;
anti-apoptotic
R+ Pramipexole: Antioxidant
Arimoclomol – FALS Heat shock protein inducer; Trial for people with ALS
secondary to mutations in the gene for superoxide dismutase 1.
Lithium: Increased autophagy, anti-apoptotic, glutamate antagonist
Any and all info or comments would be greatly appreciated...
Thanks again for sharing so freely here...It has meant alot to me!