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Muscle biopsy

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Suhernan

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My preliminary muscle biopsy report indicates slight, established reinnervation following previous denervation. Rare, recent denervation not followed by reinnervation and very slight non-reinnervation following previous denervation aka pyknotic nuclear clumps and I am wondering if any of you had results like this an onset as ALS is in my differential. I presented in 2013 and have been undergoing extensive testing since. My neuromuscular specialist says I am a very interesting puzzle. Thanks
 

FSHolbrook

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This is the one test that I did not have so, unfortunately I can not give you any information. I had many blood test, many MRIs and and EMG. Then I got to join this elite club of persons with ALS.

Rick
 

Dusty7

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Sorry, can't help. Didn't have this one.
 

affected

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this should be in DIHALS forum?
 

ottawa girl

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Moved...! Thanks Tillie

You caught me napping.
 

jellis86

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I did not have a biopsy, but my first EMG showed reinnervation following previous denervation and at that time no active denervation.

My second EMG 3 months later showed active denervation in all muscles tested.

Try to contact a guy on here by the name of Wright. Now he's an EMG expert, but he may well know about biopsy results too.
 

lgelb

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Muscle bx can be equivocal for many reasons and in themselves can't confirm or disprove ALS. The clumps can be associated w/ MG, myotonic dystrophy, etc. as well as ALS. I assume MG has been ruled out by now. The Washington U neuromuscular site has some good summaries that might help you and help you match up your most prominent symptoms.
 
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