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L4dybugg

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I was just wondering how many people on here are there, that have had a muscle biopsy, and are still not diagnosed yet? And how many of you have had one to come back with "chronic denervation and reinnervation" as your biospy results, and are still not diagnosed yet?
 

SteveS

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Hi,
My wife Micheline and I are still waiting for the results of her biopsy and it has now been about 4 weeks. We are suffering from severe anxiety while we wait. We are on our 3rd neurologist but this last one is an ALS specialist. Getting paperwork done via her GP the diagnosis that has been put down is Limb Onset ALS. We are going back to VGH (Vancouver General Hospital) for yet another round of MRI's on the 31st of this month. This will be the 7th or 8th she has had in the last 10 months or so. Seems every test she has had performed in the year that all of this started they want to repeat again. I guess just to be sure. I would hope that if they are not sure that she actually has ALS that they would not be putting that down as a diagnosis. We have adopted the mindset that it is and cling to a small ray of hope that it is something else.
 

L4dybugg

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Steve- I hear ya. That is about where we are with my husband. The waiting is very hard, but it's the not knowing what they have that kills you. I can't even imagine how they feel. It is very frustrating. My prayers are with you and your family, and I hope you get answers soon.
 

awieleba

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I had a muscle biopsy and it was 'scatterd atrophic fibers'. That is I believe acute denervation, there was no reinervation. I have no diagnosed and was told no als. After researching muscle biopsy results in a nuero book, my scatterd fibers could be the begining of als, of course NO one will agree or say it, but it is in the neuro books as that. There are alot of other reasons that I could have that, so I hold out the hope......

I wish you the best of luck in your diagnosed.....and I will pray for you, I will pray for strength--that is all I ever pray for.

april
 

wright

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April

If you have muscle atrophy (and you say you do) and other lower motor neuron symptoms (and you say you do), then your muscle biopsy would show reinnervation and active denervation if you had ALS. As soon as ALS starts you will have scattered atrophy (that is true) . . . but as soon as it progresses EVEN A LITTLE BIT . . . reinnervation will take place . . . and if it continues to progress, you will have both active denervation and reinnervation. Later in the disease process, group atrophy will be seen but that will be when muscles are becoming very atrophied. Your neuro book is not giving you the complete picture or story. Generalized neuro books typically don't.
 
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lovelily

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Hello Wright.

Does reinnervation happen in other processes, outside of ALS? And say if it does, like in a pinched nerve, would one leg get heavy muscle wasting from that process?
 

wright

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Yes, reinnervation can occur whenever there is any type of denervation.

Yes, you can have muscle atrophy whenever there is any type of denervation for lots of different conditions, including a pinched nerve.
 

awieleba

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Thanks Wright for clarifying my biopsy, yet again!

I do appreciate and I hold out the hope!
 

Zaphoon

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I'm really liking the sound of this pinched nerve thing more and more.

Zaphoon
 

L4dybugg

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Thanks Wright, that gives us some hope. ;)
 
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