AdBlock Detected

Sure, ad-blocking software does a great job at blocking ads, but it also blocks some useful and important features of our website. For the best possible site experience and to help support our community please take a moment to disable your AdBlocker.

Mouse experiment

Status
Not open for further replies.

Inventor

Distinguished member
Joined
Aug 10, 2012
Messages
204
Reason
PALS
Diagnosis
12/2012
Country
FI
State
Southern Finland
Once upon a time there was a research institute that was trying to develop a fuel for automobiles. Because cars are expensive, the institute had found a shortcut: every potential fuel was first tested on mice, and only those that showed positive results on mice, were subsequently tested on automobiles.

Gasoline was tested. Mice died of poisoning. The same thing happened with diesel fuel. Bioethanol messed up mice’s steering system. Mice that were given electricity kicked for a while but eventually went stiff.

Finally a breakthrough discovery was made: cheese. Mice fed with cheese functioned perfectly. The institute published a press release and several scientific papers were written. Money was raised to purchase 1000 automobiles and their tanks were filled with cheese.

The test produced disappointing results: the cars did not move at all. The institute published the results and started raising funds for further mouse experiments.


The story is, of course, pure fiction. Engineers are not quite that dumb.
 

mpnatx

Distinguished member
Joined
Aug 5, 2014
Messages
347
Reason
PALS
Diagnosis
11/2014
Country
US
State
Texas
"Engineers are not quite that dumb"
You got that right! :smile:
 

Inventor

Distinguished member
Joined
Aug 10, 2012
Messages
204
Reason
PALS
Diagnosis
12/2012
Country
FI
State
Southern Finland
Too bad ALS drug developers are not engineers.
 

ShiftKicker

Moderator
Joined
Mar 16, 2015
Messages
2,149
Reason
DX UMND/PLS
Diagnosis
06/2015
Country
CA
State
BC
I'm married to one, Marty and I'd happily argue with you about that depending on the day and the situation! ;) He's still confounded by which dial turns on which element on the stove. He usually ends up turning on the wrong one and wondering why the pot isn't boiling after 15 minutes.
 

Inventor

Distinguished member
Joined
Aug 10, 2012
Messages
204
Reason
PALS
Diagnosis
12/2012
Country
FI
State
Southern Finland
I see this was moved to off topic. In spite of the satirical approach, this was meant as a serious criticism on how using mice in preclinical screening will mislead the drug development process. God knows how many effective ALS drugs have been scrubbed because they don't work on SOD1 mice.
 

Nikki J

Moderator
Joined
Mar 22, 2012
Messages
7,365
Reason
PALS
Diagnosis
04/2014
Country
US
State
MA
There are clearly issues with the mouse model.

Recently in one of my FB group someone excitedly reported some positive results from a mouse study. I could only think how nice for the mouse ( though not as they generally get “ sacrificed “ to compare them to the control group)

IPS technology has brought another dimension to the game and it is very welcome. I have to say mice still have a role.

I am c9 and it took a bit to get a workable c9 mouse. In the meantime ASO was successfully tested in IPS cells. The FDA insisted on a animal model study. That study indicated serious issues ( cancer and ironically neuro issues) with that technique. They have continued to work on it and a human trial is expected soon. In this case the combination seems to have resulted in a better potential treatment

The issue is harder with so called SALS of course. There isn’t a SALS mouse and of course SALS is not a single disease any more than FALS is.
 

affected

Guru status reached
Joined
Apr 26, 2013
Messages
11,583
Reason
Lost a loved one
Diagnosis
05/2013
Country
OZ
State
home
Confused the hell outta me how this thread has jumped around the forum sections - an engineer was involved?
 

wishmobbing

Senior member
Joined
Dec 5, 2017
Messages
712
Reason
Lost a loved one
Diagnosis
07/2017
Country
DE
State
Germany
Thread fell through a mouse hole
 
Status
Not open for further replies.
Top

AdBlock Detected

We get it, advertisements are annoying!

Sure, ad-blocking software does a great job at blocking ads, but it also blocks some useful and important features of our website. For the best possible site experience please take a moment to disable your AdBlocker.

I've Disabled AdBlock