The ALS research community should stop grabbing the ALS mouse model "donut".
Animal testing for ALS drugs is a compete waste of time.
It has been shown over and over again that drugs that prolong lives of the..."ALS mouse" do not necessarily prolong lives of humans (PALS).
Why the ALS research community continues to follow this failed methodology is beyond me; and it would be funny if PALS weren't dropping like flies watching this process over and over as if it were an episode of the Simpsons where Homer demonstrates his immunity to even basic Pavlovian conditioning, grab donut get electric shock, grab donut get electric shock, grab donut get electric shock, etc...
Thanks so much for that link i will go to it now - YOU R A GEM, i have been taking melatonin at night for sometime -so i am very interested in what they have to say.. I think general health benefits outway any possible side affects - and even if it doesnt make a massive difference longerterm with degenartion - i certainly feel better for taking it..
Maybe it is also worth mentioning that melatonin had been linked to some serious adverse events such as hypertension, the release of stress hormones, inflammation, and higher mortality in animals. It seems that, in general, its temporary use might be more appropriate over long term intake.
Years ago when I was running Virginia biotechnology Association had a melatonin researcher Richmond. Constant state that laboratory quality melatonin versus what was available commercially to vastly different products. He was using a product that was USP approved they don't know that we can find that.
I do agree that continued use of that mouse model which is produced faulty so many trials as to be re-examined as a methodology.