Just started ANQUR trial - Anyone else on it?

[BetterTogether]

Hi everyone,

I was recently accepted onto the ANQUR clinical trial for QRL-201. It’s a double blind, placebo controlled trial involving a new drug administered via lumber puncturewhich targets a particular protein involved in TDP 43 issues.

More info here for anyone interested:
QRL-201

I’m based in the UK and I think I’m the first person in this country to be on the trial, but I wondered if anyone else here was on it or was considering it?

Would be great to catch up with anyone else who is. Or if you have any questions about the trial, I’d be happy to help if I can.

Thanks everyone

 

[Nikki J]

Good luck. This is an interesting trial and an approach that makes sense.

For members reading it is in a couple of sites in Canada. Also in the UK, Ireland and several continental European countries

 

[JAM]

Praying for success for you, and in turn, for all this community.

 

[powerpadman]

Keep us posting. Praying for a slowing of progression!

 

[JAM]

Better together- is this PH2 study?

 

[BetterTogether]

Just phase 1 unfortunately, though I think they call it “1b” as it’s dosing straight into ALS patients rather than healthy folks. But it’s still mostly testing for safety and tolerability at this stage.

 

[tho]

I also got recruited. Will probably start in March/April. I'm living in Germany.

 

[JAM]

Best of luck to you!

 

[csommers]

hi, has is been long enough for you to notice any differences? any issues so far? hoping for all of us that it's working.. also, i noted this: "could potentially modify disease progression and improve outcomes in ALS patients who have a loss of STMN2 due to TDP-43 pathology"

did you get genetic testing to qualify for this? how do i know if it'sTDP - 43 pathology?

 

[JAM]

@BetterTogether
How is the trial going? Hoping well for you!

 

[BetterTogether]

@tho - thank you for taking part and let me know how you get on with the trial!

@csommers - TDP43 protein misfolding and aggregation is very common in ALS, more than 95% of patients have it, so it’s a great target for a trial drug (I didn’t get screened for TDP, but there were a lot of other tests!)

 

[csommers]

Hi, just curious to know if you feel it's helping slow the progression?