- Mar 16, 2015
- DX UMND/PLS
Development in more efficient drug delivery across the blood brain barrier.
First-in-human trial of bloodâ€“brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
MR-focused ultrasound can be used to transiently open the blood-brain barrier (BBB). Here, the authors report the results of a first-in-human trial on four patients with amyotrophic lateral sclerosis (ALS), showing that the procedure reversibly permeabilised the BBB in the motor cortex without...