Edaravone

[Nikki J]

This is the edaravone study using a formulation developed in Europe. It definitely raises questions about radicava and I encourage people to discuss this with their neurologist. I don’t take radicava and never thought it worth pursuing but i am almost as different from the Japanese trail responding group as can be

Ferrer reports top-line results from Phase III ADORE study in ALS | Ferrer

Ferrer reports that Phase III ADORE (EudraCT 2020-003376-40 / NCT05178810) clinical trial of oral edaravone formulation (FAB122) in amyotrophic lateral sclerosis (ALS) patients did not meet primary or key secondary endpoints.

www.ferrer.com

 

[Clearwater AL]

“Data from ADORE indicates that product did not show significant
benefit over placebo in patients with ALS in slowing the disease
progression.”

“No improvement over placebo on long-term survival was observed
as measured by CAFS at 48 weeks and 72 weeks for a subgroup of
patients.”.

Yet (me)…”The results of the study also concluded that the product
was safe and well-tolerated.” ?? For what ?

Am I missing something here ? My thought is… why bother ?

 

[Nikki J]

Meaning they found it won’t make you sick but it won’t help you either. Adverse events are tracked in trials so they were just being complete and probably also emphasizing they did no harm. The c9 biogen aso not only failed it made people worse at the highest doses so it can happen.