I agree, Nikki. Dr. Bedlack is very knowledgeable and approachable. I think we need physicians like him that are willing to be creative, even if he is a bit unorthodox. And I have no issue at all with him trying to make sense of the “reversals,” though that may not be the best word to describe the phenomenon in those 40+ cases he has identified.
I also agree with Laurie re: the Italian study and measurement issues. Measurements with most ALS drug trials are challenging and often rely in part on the subjective rating scale for muscle function, lacking clear biomarkers. Not to mention the limited number of participants in most trials.
I guess the question that first came to mind was why, if the Italian study showed improvement, was there not any larger follow-up study done in the 15 years since that work. It’s seems like it fell into obscurity until it was “rediscovered” by Bedlack, which is odd to me.