- Apr 2, 2008
I am confused. The John's Hopkins website attempted to differentiate between the symptoms found in PLS compared to ALS. They said that it mainly affects the legs and you get leg cramps. It said one of the main differences between the two is that PLS does not have twitching as a symptom. So now I don't know what to think. I always thought that if you have clean EMG's consistently that is more likely PLS regardless of symptoms such as twitching. They also said PLS is so much more rare than ALS. Anyone have any thoughts on this?