Thank you for replying Al,
He is taking 1000mg Q10, 800mgE, 2.5g creatine, 100mg grapeseed, acetyl-Lcarnetine, Alpha-lip-acid, pychnogenol, DHEA and 3-4,000 Flax Seed/Fish oil. Since the inital diagn. the only visible signs remain the loss of coordinat. between the thumbs/index along with muscle waste in that area only. If he "over-uses" his hands, the strength in the hand/fingers just shuts off, then it comes back after time, the length of time depending on how much he used them. From the left hand the same thing has happened to the right hand, not as much yet, and it appears to stay at that one level. While there are fascic on the calf and thigh of the left leg (there the cramps were the most vicious back in Oct/Nov 04), and less on the right leg, he has no problem at all with his legs. We now realize, that the fascic and cramps had started back in the fall of 2003, but he has always attributed anything like this to heavy workouts and his work (masonry). We are doing everything on our own, that is why I rely so much on the exchange of information. We all have to learn from each other's trials and errors since there is no help form the medical establishement. Dad feels much better than the time he went to the doctor's. We do not know which one of the supplements may be helping, so he takes all in a daily routine, along with good fruits, veg, no red meat, addl protein shakes diet. He has good appetite, no loss of weight at all; he works out (low impact bow-flex) and thread-mill walking. No range of motion is affected at this time. I keep a daily record of everything he takes and of how he feels. After the inital devastating and very morbid 2 months following the diagn, our entire family felt we were given a death sentence-feeling everyone on this site knows only too well. Dad considered the worst and opted to proceed as if this will be overcome; there is no other choice. I have read everything I could find for months now and know what you mean about the fascic. What I was wondering is, if eliminating the cause of the cramps, in some way may have eliminated (I know, I may be just hoping) or at least slowed down the reason for the inital nerve destruction in the muscles. The cramps were at their height during and right after a very heavy work season, with a lot of aggravation. Now, he is not working anylonger, he is much calmer, focused on staying calm (huge change in behaviour) and this seems to have had an impact. Does it sound reasonable to you? Or am I being naive?