Hi Ting, My husband was diagnosed in September last year. We live in Raleigh and are working with Duke ALS Clinic. I would start by calling Duke ALS and explaining the situation. I got my husband in earlier than the standard 3-month wait by calling every Monday morning to see if there were cancellations. Duke will help diagnose ALS, treat symptoms, and enroll your mother in a clinical trial if she is eligible. Dr. Bedlack is world-renowned, and Duke ALS was treating patients from every US state, Europe, and Brazil when I casually asked. The clinic is only open on Tuesdays, but the specialists work until they see every patient, sometimes late into the night. Durham is 2 hours from Charlotte, so you will need to stay overnight. I would be happy to help you find a hotel, navigate the appointment, and explain what to expect. I don't know how to do so, but if someone could tell you how to PM me, I'll give you my phone number so we can talk more easily if you'd like. My experience is that it would be well worth the drive to get your mom into Duke ALS Clinic.