Had my 4th week in the trial checkup today. 4th week includes a sonogram of your gall bladder, lung function, and a full battery of strength assessments. I can report that I didn't improve in any area and lost ground a bit in a number of areas (hands and legs) - but not everywhere. My lungs didn't change, for instance. ,And no gall bladder problems, but I still have the same problem that makes me think I am actually geting the drug. But, I'm still walking (with a cane) and working. I guess I'm cautiously optimistic that this might be doing some good.