Hi Kelly,
Such a great coincidence, I was just getting some great advice from cris about the same topic. Go to my profile and you can see her great advice for Exuderm. My mom has a really big sore developing and skin breakdown all down the sides of her nose from the mask. Before cris's great advice, we tried aloe, liquid bandaid and other topical stuff - nothing really worked and some of it made mask really slippery on her face.
We switched to a mask with nose pillows in order to give her nose a break. The nose pillows work great, although sleeping in it is a bit tricky, but she is trying that. You need to make sure to get the right size for the nose pillows, exact insertion into the nostrils is key.
I also see on cpapXhange.com what they call total face masks that would be good only for sleeping, as the eye irritation would be tough during the day. Others may have tried that version.