Any update on Dr.Martin Marsala study.

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ann7878

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CALS
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05/2021
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CA
What is the update of injection of virus-delivered gene silencer headed by Dr. David Marsala.
 
Martin not David I believe you mean? It looks to be the same basic method that was already tried in humans by Dr Brown at UMass when they published. Dr Brown‘s therapy has a phase 1 sod1 trial that is supposed to start soon ( the first 2 people dosed were for proof of concept)

Dr Marsala does not seem to be pursuing this currently though he is still working on ALS Martin Marsala | UCSD Profiles
 
Thanks Nikki. This sounds promising. Does it include both sporadic and familial?
 
No as in Dr Marsala’s mouse study it specifically targets the sod1 gene mutation. There is a version for the C9orf72 mutation in the preclinical pipeline but this type of therapy needs a mutation to target

some other FALS research will help sporadic though as they are looking at pathways that are implicated in FALS and SALS
 
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