1. P

    Spastic paraparesis question

    I was recently told by the neurologist that he thinks I have hereditary spastic paraplegia, I was wondering if anyone could tell me if this comes in flare ups/exacerbations. Because I can't find anything about that question. Thank you in advance.
  2. S

    How does UMN and LMN damage coexist?

    Hi all, I have read this board everyday for four years, and there is something I'm still unclear on. I was hoping someone might be able to explain it to me here (for those of you who don't know me, I usually post on the PLS board. I have a UMN diagnosis of hereditary spastic paraplegia that...
  3. M

    Familial ALS? Scared from symptoms.

    Hello, I'm a 35 yr old female. My dad was diagnosed with ALS when he was 33 - and he passed away at 36. My dad had a cousin who also died of ALS, but I know nothing beyond that. I've recently seen a neurologist, due to being referred to one by an Ortho doc, after some strange symptoms. I'm...
  4. S

    Back to the NIH

    Hi all, Well, as my title suggests, I'm headed back to the National Institutes of Health tomorrow in Washington, DC. As many of you know, I was originally diagnosed with the upper motor neuron disorder, hereditary spastic paraplegia, but a change in symptoms, no family history, and ambiguous...
  5. S

    In Michigan for opinion number ... six?

    Hi all, As I've mentioned here before, I've been trying to pin down a definitive diagnosis for the past two years or so. I was diagnosed with hereditary spastic paraplegia at Houston Methodist, but I don't have a family history or clear genetic evidence. My symptoms have changed a lot...
  6. S

    Going to NIH for research study

    Hi all, As my title suggests, I am headed to the NIH (National Institute of Health) on Monday to take part in a research study on inherited neurodegenerative disorders. My current diagnosis is hereditary spastic paraplegia, but I have no family history of it and my symptoms don't really...
  7. S

    Hand atrophy

    Hi all, I usually post in the PLS section since I've been diagnosed with a pure upper motor neuron disorder, but I wanted to post this here. The disorder I've been diagnosed with, hereditary spastic paraplegia, typically affects mostly the legs and generally does not cause atrophy, a lower...
  8. S

    Back on the diagnostic merry-go-round

    Hi all, As many of you know, I was diagnosed with Hereditary Spastic Paraplegia last summer. The only definitive way to diagnose it is through genetic testing, which I had done recently. My results did show a mutation, but it was a rare one of "unknown certainty". So, it might be the...
  9. Nikki J

    PLS study

    I copied this from a post in another group PLS study, at Mass General in Boston, Dr. Paganoni recently received the Virginia Sweeney Fellowship to study PLS from the Spastic Paraplegia Foundation. MGH is one of a few facilities in the world to do a combined MRI-PET scan. They have been doing...
  10. BlueTrain

    First Post - Not Yet Diagnosed

    Mod note: this member's journey has caused much concern among those worried about ALS. It is extremely important to note that his initial clinical exam was very abnormal ( far more so than brisk reflexes alone which can be normal). It was clear from the start that he had upper motor neuron...