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I have heard of a new compound (to me) that is like CBD but NOT CBD. It is called CBG. I saw the information from a company that is reputable, has their products independently tested, and I have bought from before. I wont mention the company, because, that is not the point. I just have some...

I have PLS and a lot of Hyperreflexia. No Hyporreflexia. Hyper being upper motor neuron dysfunction and Hypo being lower. But I often hear people talk about Hyper in relation to ALS. Why is that? Wouldn't ALS be Hypor, or both? Why is Hyper a sign of ALS? Does it appear before Hypor? As a...

I am wondering if anyone has tried either Dalfampridin or Kepra. I have heard mixed reviews about both of them. There is an ongoing study for Dalfampridin in PLS. I think both are off label right now for PLS. I tried Baclofen but it made my walking worse. I am currently on Tizanidine. It...

Does weight training help with PLS? It seems to keep me strong and I have had very little weakness with my PLS. The only negative is that it makes my stiff legs even more stiff. This is because I have the stiffness from the exercise on top of the PLS stiffness. I hope to hear form TxRR...

There are some closed threads on this subject but I am new and need some help. I was recently diagnosed with PLS and am a veteran. I have submitted two letters form neurologists stating that PLS is a variant of ALS. I tried twice to get the VA to grant me disability but they keep denying it...