So long as there are no issues with load bearing walls, you should be fine. (we almost made the DR my bedroom, chose the family room instead, that way I have the deck off of it)
Look up the ADA code standards, they're actually helpful, and remember to take into consideration existing duct work. And, if there is a wall problem, you could maybe make it a half wall or use glass block and make it part of the shower somehow, YKWIM
For shear beauty, Mare has pictures posted of a beautiful bathroom modification, and she told me she plans to post more, as they did more...
Your house is so charming, if it were mine I'd be hard pressed to find the heart to try to sell it!