February 2016

Respiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS)

Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Device: PowerLung trainer;   Device: Micro Mouth Pressure Meter;   Procedure: Pulmonary Function Testing;   Procedure: Videofluoroscopic swallowing study;   Other: Swallowing Quality of Life Questionnaire;   Device: Iowa Oral Pressure Instrument;   Drug: Capsaicin
Sponsors:   University of Florida;   ALS Association
Recruiting - verified September 2016

Sequential, Related Donor Partial Liver Transplantation Followed by Bone Marrow Transplantation for Hepatocellular Carcinoma (HCC)

Conditions:   Fibrolamellar Hepatocellular Carcinoma;   Hepatocellular Carcinoma (Fibrolamellar Variant);   Hepatocellular Carcinoma
Interventions:   Procedure: living related donor partial liver transplantation;   Radiation: Total body irradiation;   Procedure: Bone marrow transplant from same donor;   Drug: Cyclophosphamide;   Drug: Mesna;   Drug: Filgrastim;   Drug: Tacrolimus;   Drug: mycophenolate mofetil;   Drug: Prednisone;   Drug: Antithymocyte globulin;   Drug: fludarabine

Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS

Condition:   C9ORF72 Amyotrophic Lateral Sclerosis (ALS)
Intervention:  
Sponsors:   Washington University School of Medicine;   Cedars-Sinai Medical Center;   UMC Utrecht;   Johns Hopkins University;   Sentara Health Care/Sentara Neurology Specialists;   Massachusetts General Hospital;   University of Massachusetts, Amherst;   Biogen;   ALS Association;   Columbia University
Recruiting - verified January 2017

Tongue Motor Recruitment During Exercise

Condition:   Healthy
Interventions:   Procedure: Electromyography;   Procedure: Maximum expiratory pressure;   Procedure: Videofluoroscopy;   Behavioral: Swallowing Tasks
Sponsor:   University of Florida
Completed - verified January 2017