Terry,
Ask your neurologist at the VA. The VA policy on the usage of Edaravone:
2017
Edaravone (Radicava) Criteria for Use July 2017 VA Pharmacy Benefits Management Services, Medical Advisory Panel, and VISN Pharmacist Executives
The following recommendations are based on medical evidence, clinician input, and expert opinion. The content of the document is dynamic and will be revised as new information becomes available. The purpose of this document is to assist practitioners in clinical decision-making, to standardize and improve the quality of patient care, and to promote cost-effective drug prescribing. THE CLINICIAN SHOULD UTILIZE THIS GUIDANCE AND INTERPRET IT IN THE CLINICAL CONTEXT OF THE INDIVIDUAL PATIENT. INDIVIDUAL CASES THAT ARE EXCEPTIONS TO THE EXCLUSION AND INCLUSION CRITERIA SHOULD BE ADJUDICATED AT THE LOCAL FACILITY ACCORDING TO THE POLICY AND PROCEDURES OF ITS P&T COMMITTEE AND PHARMACY SERVICES.
Inclusion Criteria The answers to one of the following must be fulfilled in order to meet criteria.
“Definite” or “probable” ALS according to El Escorial revised Airlie House diagnostic criteria (
http://www.alsa.org/assets/pdfs/fyi/criteria_for_diagnosis.pdf)
AND preserved ability to self-feed or walk
Monitoring
Patients should be monitored for respiratory function and ALSFRS-R scores
ALS Functional Rating Scale at baseline and every 6 months.
Changes in ALSFRS-R scores should be evaluated for continued therapy with edaravone.
Discontinuation Criteria
Patient becomes dependent on ventilator support during the day and at night (Items 10, 11, 12 on ALSFR-R with score <1)
Patient becomes wheelchair bound (if patient initially met CFU with ability to walk) ( Item 8 on ALSFR-R with score <1)
Patient requires full assist with eating (if patient initially met CFU with ability to feed) (Item 5a on ALSFR-R with score <1)
Additionally, a discussion with the patient/caregiver/family regarding realistic treatment expectations and discontinuation of therapy should be documented in the patient’s EMR.
Exclusion Criteria If the answer to ANY item below is met, then the patient should NOT receive edaravone
□ Notably decreased respiratory function and dyspnea (a score of ≤3 points on ALSFRS-R items for dyspnea, orthopnea, or respiratory insufficiency[ the sum of questions 10,11 and 12 on the ALSFRS])
□ Bilevel positive airway pressure (BiPAP ) dependent (use 24 hrs per day)
□ Complications that might influence evaluation of efficacy (e.g., Parkinson’s disease, schizophrenia, significant dementia, other major medical morbidity)
□ Other possible causes for current symptoms not ruled out (e.g., cervical spondylosis or multifocal motor neuropathy)