Hi Mike, I think that research concerning the biochemistry of the ALS disease process is important. As in most research, more questions are raised than answers, but that is par for the course. Hopefully, someday, further understanding will lead to more effective treatments and a cure. I do not have my dad's test results, and do not know if he was tested for cytokines or the TNF alpha response. I could ask my mom if she has kept all of the paperwork, though they may not have given her that particular information. Are these levels usually measured in PALS during diagnosis, or was it done just as part of those studies?