riluzole and omeprazole

[nebrhahe53]

I was prescribed omeprazole for GERD by the gastroenterologist who is going to do my g tube but looking at drug interactions omeprazole (prilosec) decreases the level of rilutek in the blood-not good for ALS. Any ideas of what to do?

 

[Schmidhogan]

I take a PPI two times a day (Nexium) plus a drug called Remoran (sp?) for GERD. Didn't know they were contraindicated for Riluzole. Very interesting.

 

[nebrhahe53]

Do you mean Remeron Alex? Thats an SSRI. Interestingly I find no interactions between Nexium and Rilutek

 

[lgelb]

Remeron is not an SSRI. It's a TeCA.
But anyway, you may be better off w/ pantoprazole (Protonix) in terms of PPIs. It's a weaker inducer of the enzymes involved in any riluzole interaction (which is putative based on mechanisms, not empiric studies). Same effects on GERD.

 

[Schmidhogan]

Generic name is metoclopramide.. It can have some nasty side effects but I've been ok with it. Alex

 

[nebrhahe53]

you are correct lgelb my mistake, Remeron in not in the SSRI class although it is used for the same types of symptoms as SSRI's

 

[nebrhahe53]

Ah you mean Reglan Alex

 

[Schmidhogan]

They both start with rs. I think I take both of them. One at night for sleep and appetite enhancement, the other three times a day to aid in stomach emptying and GERD. Sorry. Alex

 

[gooseberry]

I have taken gerd meds for a long time. My gastroenterologist has always told me to stagger them by 2 hours from any other med so they don't interfere with absorption. I take the Gerd med once a day in the middle of the afternoon.

 

[ECpara]

Oh my, did not know that. Tom is on both - omeprazole is for the bleeding ulcers he was hospitalized for in March. So far I can't say I see any more rapid progression. Then again, does Rilutek really make that big a difference?

 

[MaxEidswick]

>Then again, does Rilutek really make that big a difference?

hope so

 

[GregK]

> Then again, does Rilutek really make that big a difference?
Hard to tell. But better to take it 'just in case' than to lose the chance....