UMN Dominate ALS and PLS

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Mike in Maine

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Joined
Oct 18, 2013
Messages
244
Reason
PALS
Diagnosis
10/2013
Country
US
State
PA, No longer live in ME
City
Pocono's
The last two Doctors I have seen, my normal Neurologist and a ALS specialist used UMN Dominate ALS and PLS inter-changeable, they both viewed ALS as continuum with PLS or UMN ALS at one end and UMN/LMN ALS on the other. What are your thoughts on this? I posted this on the PLS side and only received 1 response. I really interested in your feedback, because my regular doctor is now using the UNM ALS and I’m wondering how this changes the path I’m following.

Thanks Mike
 
My husband's Neuro said he was UMN dominate too. he is very slow progressing. He also does have LMN signs, so that is what I always was told is the dif between ALS and PLS. His Neuro also uses the Spectrum/Continuum reference --it does make sense when you think about how differently people present and move thru this disease.

here is what I have been told--but I don't mind being corrected if I am wrong...UMN and LMN affect the nerves and muscles differently--so there are different symptoms of each. Flaccid, weak=LMN, spasticity, fasciculations=UMN. If you have both, you have ALS but you can be more one than the other, thus the spectrum. at either end of the spectrum is pure UMN or LMN, which is PLS or PMA.

UMN dominate is slower moving, LMN is faster moving and LMN affects the breathing/diaphragm.

For instance, My husband's still fighting at almost 7 years. his arms are flaccid and useless, his legs are spastic but weak--he can still support his weight on them for a few minutes. his neck is weak and can not hold his head up with out support, but his jaw is spastic and clenched. he still eats pureed food by mouth because his swallowing is good enough. his breathing is shallower and faster than normal, but certainly not bad considering the condition of the rest of his body.

Just giving you something to compare. being UMN dominate is a good thing for longevity!
 
My husband is LMN dominate, and his ALS doctor told him it would be a slower progressing disease. This has not proved out, as he first started showing signs Mar/12 and now is almost a total quad, and diaphragm very weak. His neck, jaw and swallow normal, but breathing noticeably weakening. So I think I agree with you Barbie.
 
I thought fasciculations are LMN but I could be wrong. Does anyone know for sure?
 
fasciculations are LMN related, these show up on an EMG and help determine, along with UMN signs, whether it is ALS.
 
That is a very good link Joel!~
 
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