| | Re: Any non-familial PALS have relatives with ALS?
You raise an interesting question.
As far as I am aware, there is no history of anyone in my family ever having ALS except me.
I was not aware that there were so many different forms of familial ALS until you pointed it out; however, the majority of them are autosomal dominant - which, as far as I remember from my biology classes, means that one of my parents, one of my grandparents and one of my great grandparents would have had to have ALS. None of them have/did.
But I guess none of us can be 100% sure without genetic testing. It could be that one of parents has the ALS gene but hasn't developed the disease yet. It could also be that each of my ancestors carrying the gene died before developing ALS or were not properly diagnosed.
It could also be that both of my parents carry the same recessive ALS gene.
But this could be the case for any PALS and we are dealing with pretty low probability. I'm not sure of the exact percentages, but I would say I am 98-99% certain that I don't have familial ALS.
If this potential relative who has ALS is actually related to me, he is at least 200-300 years removed.