Old 04-16-2019, 06:26 AM #1 (permalink)
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Default heredity question

Hello everyone. My first post. I'm Deb from Australia. scared to say much right now. I'm actually waiting for a diagnosis and "incidentally discovered my grandmother died of pneumonia secondary to ALS in 1970. I read in Google scholar that not all people with the faulty gene will progress to ALS. What have you heard. Thanks Deb
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Old 04-16-2019, 07:17 AM #2 (permalink)
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Default Re: heredity question

First one relative with ALS is more than likely what is termed SALS sporadic ALS. SALS occurs apparently randomly and children are only slightly at increased risk over the general population. This is because people with SALS are believed to have a slight predisposition that is triggered only because they were exposed to a series of ( currently unknown) triggers

There are multiple gene mutations that have been found in FALS. Most are autosomal dominant but have varying penetrance. This means that the chance of a carrier getting ALS is different depending of which mutation. It varies from almost 100 percent to much less

An offspring of a mutation carrier has only a 50 percent chance of inheriting the family mutation. If they don’t their increased risk is none
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