Old 01-01-2009, 01:21 PM #1 (permalink)
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Default Question about mice with ALS?

How do researchers induce ALS in mice if they don't know what causes ALS?
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Old 01-01-2009, 02:49 PM #2 (permalink)
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Probably they play tricks with the auto immune system or cut off nutrition fed to the muscles from the nerves somehow............because that's what ALS does, I understand.
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Old 01-01-2009, 02:49 PM #3 (permalink)
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Don't know for sure, but I think the mouse studies are done on the familial form of ALS - they think they know which gene is related to this.
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Old 01-01-2009, 05:19 PM #4 (permalink)
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They use mice that have the SOD1 mutation related to familial ALS. It expresses the gene approximately 30 times more than humans. For more info Google G93A-SOD1.
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