- Joined
- Nov 18, 2014
- Messages
- 4,873
- Reason
- PALS
- Diagnosis
- 08/2015
- Country
- US
- State
- South
- City
- The Beach
A protein in motor neurons called p75 is important in early life, but doesn’t appear in adults unless motor neurons are injured. Previous studies in mouse models of ALS found that p75 was re-expressed in motor neurons as the animals became sick. The part of p75 that sticks out from the cells—its extracellular domain (p75ECD)—was found in the urine of the mice even before they exhibited muscle weakness.
From what I've read, this marker can track progression and it can be measured by a urine test.
From what I've read, this marker can track progression and it can be measured by a urine test.