Caliburn
Active member
- Joined
- Feb 27, 2013
- Messages
- 55
- Reason
- Learn about ALS
- Country
- US
- State
- RI
- City
- Lincoln
I know there has been some studies on the efficacy of an Adeno-Associated Viral Vector (containing RNA for up-regulating the expression of the PSA/NPEPPS genes) in mouse models, and it has been show to greatly impede neuro-degeneration in a couple of different genetic mouse strains mimicking various neurodegenerative diseases including ALS. The study im providing the link for specifically focuses on ALS and shows that this PSA/NPEPPS gene has been shown to break down aggregates of misfolded SOD1 found in sporadic and familial ALS. i cant remember if it has extracellular efficacy as well, but this article certainly provides scientific hope that progress is being made. (this is the article focusing on PSA/NPEPPS in ALS)
http://www.biomedcentral.com/content/pdf/1750-1326-6-29.pdf
if only a cure was as simple as injecting a 0.0235 M solution of Trypsin into the spinal cord and/or brainstem....but of course that would have terrible consequences.
Some day this disease will be a distant memory, and the sooner that day comes the better.
Caliburn
http://www.biomedcentral.com/content/pdf/1750-1326-6-29.pdf
if only a cure was as simple as injecting a 0.0235 M solution of Trypsin into the spinal cord and/or brainstem....but of course that would have terrible consequences.
Some day this disease will be a distant memory, and the sooner that day comes the better.
Caliburn