Old 03-30-2010, 10:29 AM #1 (permalink)
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Thumbs up immune system research into ALS treatment

Hi folks...came across this article today which sounds interesting......stu

Novel Therapeutic Slows Progression and Extends Survival in Preclinical Model of Disease

CAMBRIDGE, Mass., March 28 /PRNewswire-USNewswire/ -- In an article published in Nature Genetics today, scientists at the ALS Therapy Development Institute (ALS TDI) describe how they have linked an unbiased gene expression profiling effort to the identification and successful preclinical testing of a potential novel therapeutic for amyotrophic lateral sclerosis (ALS).

The work adds to the body of evidence for immune system involvement in ALS, and focuses new attention on immune system modulation as an approach for treatment. The authors report that blocking the interaction between two immune system molecules can significantly slow disease progression in a mouse model of ALS.

The therapeutic, ALS TDI 00846, blocks activation of a cell surface protein, CD40 ligand, and modifies a key immune system response not previously known to be associated with the progression of amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease). In their research, the authors show that the pathway used to identify ALS TDI 00846, is also increased in 56% of the ALS patient samples analyzed by the Institute. Although ALS is commonly thought of as a disease of the central nervous system, this novel disease-modifying treatment was shown to directly affect the activity of classes of immune cells responsible for maintenance and repair of the peripheral nervous system.

"Of the five pathways we found, two are associated with T cell activation, two with macrophage activation and one pathway contains genes involved with co-stimulatory regulation of the immune systems. Because we could slow the disease, at least in the mice, when we blocked the co-stimulatory pathway with ALS TDI 00846, we believe that we have implicated an immune process that may drive the degeneration of neurons. It is our hope that this work will open up a new class of therapeutic strategies for ALS," said John Lincecum, Ph.D., associate director of research biology at ALS TDI and co-author on the paper with the Institute's director of in vivo operations, Fernando Vieira, M.D.

Specifically, the report entitled, "From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis," details the characterization of the co-stimulatory pathway, which is a key regulator of immune system response, and the development of ALS TDI 00846 as a therapeutic biologic. The preclinical development of this potential treatment for ALS was made possible by multi-year grants from the Muscular Dystrophy Association, the Department of Defense, and the RGK Foundation, as well as from donations received from hundreds of people living with this devastating neurodegenerative disease.

"ALS TDI was built to overcome the drug development gap for ALS, meaning the lack of connections between target discovery and therapeutic development. Our infrastructure, which is paid for entirely by the ALS community, is specifically designed to bridge this gap. With this paper we begin to show the full potential of this approach," said Steve Perrin, Ph.D., chief executive officer and chief scientific officer of ALS TDI.

Prior to publishing in Nature Genetics, ALS TDI scientists presented early results and data to the field at several high-profile scientific conferences throughout 2009, including the annual meeting of the Society of Neuroscience in Chicago, the BIO International Conference in Atlanta, the first annual Partnering for Cures conference in New York, and the annual International Symposium for MND/ALS Research in Berlin, Germany.

"What the team in the lab has accomplished in terms of discovery and development is unprecedented, and something that the entire ALS community can be proud of. We believe that the next logical step for this molecule, ALS TDI 00846, is that it be advanced into the clinic for trial as soon as possible, and that is exactly what the executive team is focused on doing. However hopeful we are that this drug will be successful in slowing disease down, we know that we must continue to discover and build additional therapeutics so that all those affected by ALS have the chance to fight," remarked Augie Nieto, chairman of the board at ALS TDI, via email. Nieto was diagnosed with ALS in 2006 and has raised more than $21 million for ALS research. In addition to leading the ALS TDI board, Nieto is a national vice president of MDA and co-chairs its ALS Division along with his wife, Lynne.
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Old 04-03-2010, 10:10 PM #2 (permalink)
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Default Re: immune system research into ALS treatment

thanks , might explain why what i believe to be a good amount of pals have thyroid issues ..
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