Monoclonal Antibody Trial, ph II: Ozanezumab

[GregK]

Appears to have just fired off recruiting. I can't find any US center emntioned, however.

This is pf II for Ozanezumab (GSK1223249):

Ozanezumab (GSK 1223249) is a drug that targets a protein called Neurite Outgrowth Inhibitor (Nogo-A). It is a monoclonal antibody, which is a substance that the body makes in immunity to prevent the action of a particular protein. Nogo-A blocks neurons from growing toward muscle once the connection has been made. When motor neurons degenerate and the connection becomes weakened, Nogo-A would work against keeping that nerve/muscle contact strong. Increased Nogo-A has been observed in muscle of people with ALS and ozanezumab delayed symptom onset and improved survival in ALS model mice. Thus, it is hoped that it will preserve muscle function and slow the rate of ALS progression in humans.​

Above from ALS Society of Canada

I would think the side effects from an antibody would be less than from a 'drug'...

 

[GregK]

well, much to my non-delight, the University of Colorado HJospital is NOT one of the sites. arg.

 

[GregK]

And here are the locations that WILL be participating:



Investigator Address Work Phone
3901 Rainbow Blvd. MS 2012 Kansas City Kansas United States 66160
9135886094

55 Fruit Street Bigelow 1256 Boston Massachusetts United States 02114
6177265097

Medical Center Blvd Sticht Center Winston-Salem North Carolina United States 27157
13367166704

200 Jefferson S.E. Grand Rapids Michigan United States 49503
6166855314

740 S. Limestone Street Kentucky Clinic, Rm. L-445 Lexington Kentucky United States 40536
8592185061

1645 Neil Avenue Hamilton Hall Columbus Ohio United States 43210
6142923545

750 East Adams Street Syracuse New York United States 13210
3154645022

 

[laurel]

Greg that trial sounds interesting. Thanks for posting the information.

 

[pearshoot]

have e-mailed ku med cntr seeking info but no response yet. completed two drug trials there

 

[jennifer79]

Hi!

Is there a easy way to keep up with all the new clinical trials that are recruiting. My dad was just diagnosed last week and it is a little overwhelming. I just don't want him to miss any chance he can get.

Thanks
Only By the grace of god can we make it thru each day!

 

[momap53]

NEALS has a site on line that lists trials in US along with inclusion, exclusion criteria .

Look for north east ALS consortium dot org .