Tamoxifen

[hkmke]

Has any one heard of Tamoxifen which works to rescue the motor dysfunction of the TDP-43 mice? Apperently Rapamycin could also work, but Tamoxifen has less side effect.

Thanks

[ghost_writer]

Dear hkmke, click the tag below for other posts. Sorry I don't have any other specific information about the mice or Rapamycin.

[glupavomomiche]

hkmke,

I have an online PALS friend who attended clinic at Forbes Norris. When he was first diagnosed (about 8 years ago), that clinic automatically gave all the PALS Tamoxifen. Apparently there were some women who had had breast cancer that were taking it, then they were also diagnosed with ALS, and they all had slower progression. The only common factor amongst them was the Tamoxifen, so that's what everyone was taking. I never heard anything more about it. But just food for thought.

[SueG]

There is a phase II trial underway comparing creatine and tamoxifen. As I understand it (and I may be wrong) , whichever "wins" will go to Phase III. Better info at ALS Clinical Trials | ALS Clinical Research | The Northeast ALS Consortium (NEALS)

Sue

[John1]

I took tamoxifen from January 2001 to May 2003 with no discernible slowing of progression. I haven't seen it touted as a benefit for ALS since then. Interesting that it is being resurrected on the research front. For that matter I haven't seen creatine recommended either for about the same length of time. I wonder why someone is resurrecting these old ideas.

I used to get some funny looks from my pharmacist when I had my rx filled.