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Old 09-27-2004, 01:59 AM #2 (permalink)
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R(+)ALA should be taken as part of a trio along with Acetyl-l-carnitine and biotin. I am taking 750 mg of the potassium salt of R(+)ALA daily in divided dosages, along with 8mg biotin, and 4 grams of ALCAR.

The typical racemic form of ALA has been shown to "significantly" increase the lifespan of the transgenic mice. (See study below). You might notice that a copper chelator has also been shown to extend lifespan in these animals. This may be because copper is actually responsible for forming much of the ROS in the first place, through a process known as the "fenton reaction".

I don't want to give false hope. This is just an idea of mine, based on the fact that it has been shown effective in the mutant rodents. The study is below. These three supplements are available from many sources on the internet. Many already healthy people take them daily for anti-aging purposes.

Exp Neurol. 2001 Apr;168(2):419-24. Related Articles, Links


Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.

Andreassen OA, Dedeoglu A, Friedlich A, Ferrante KL, Hughes D, Szabo C, Beal MF.

Neurochemistry Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

The development of transgenic mouse models of amyotrophic lateral sclerosis (ALS) allows the testing of neuroprotective agents. We evaluated the effects of five agents in transgenic mice with the G93A Cu,Zn superoxide dismutase mutation. A novel inhibitor of poly(ADP-ribose) polymerase showed no effects on survival. Desmethylselegiline and CGP3466 are agents that exert antiapoptotic effects in vitro by preventing nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase. They had no significant effects on survival in the G93A mice. Trientine, a copper chelator, produced a modest significant increase in survival. Similarly administration of lipoic acid in the diet produced a significant improvement in survival. These results therefore provide evidence for potential therapeutic effects of copper chelators and lipoic acid in the treatment of ALS.
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