I don't have ALS, but do have an interest in reading up on degenerative diseases,
for which I use Medline quite a bit.
Possibly the following studies may be useful to you.
An in vitro screening cascade to identify neuroprotective antioxidants in ALS.
An in vitro screening cascade to identify neuroprotective antioxidants in ALS
Note that the above study identified the following :
Resveratrol
Esculetin, also spelled aesculetin
CAPE, or caffeic acid phenethyl ester
Resveratrol supplements are popular in health food stores.
Note that resveratrol, however, has poorly bioavaibility, a very short half-life
and penetrates the blood-brain barrier or CNS poorly, as the study also noted :
" ..... although the in vitro studies have mostly been successful, they often require
high doses of resveratrol and in vivo studies have shown rapid metabolism and
failed to detect resveratrol in the CNS. Taken together, this suggested that
resveratrol is unlikely to be effective in vivo. "
An alternative to resveratrol is pterostilbene, which has increased bioavailabilty,
longer half-life and penetrates the CNS better. Pterostilbene supplements
can be found in health food stores, though quite expensive.
Escelutin is a metabolite of escin, or aescin, the flavonoid found in horse chestnut,
or aesculus hippocastanum. Escin is commonly found in hemorrhoid creams and
formulas for hemorrhoids and varicose veins, since horse chestnut improves vascular
insufficiency.
I'm no biochemist, but I believe the cascade is :
Escin > Esculin > Esculetin
You can't find esculetin as a supplement. However, a check shows that there
are manufacturers in China, though they supply it only in bulk. These are listed
in sites such as Alibaba.com .
CAPE, or caffeic acid phenlyester, is a phenol found in propolis. There is a New Zealand
manuka product developed by a Japanese which is a popular source of CAPE, for which
you can search Google, since I believe I won't be allowed to provide you the link here.
As I know, Yvonne Foong, the Malaysian girl with neurofibromatosis 2, has been
taking it for her condition, and she mentioned she is quite happy with it.
Caffeic acid phenethyl ester - Wikipedia, the free encyclopedia
Neuroprotective effects of creatine.
Neuroprotective effects of creatine. - PubMed Mobile
DL-3-n-butylphthalide extends survival by attenuating glial activation in a
mouse model of amyotrophic lateral sclerosis.
DL-3-n-butylphthalide extends survival - PubMed Mobile
3-n-butylphthalide, or 3nB, is found in celery. There are celery supplements
standardized for 85 per cent 3nB which you can find in health food stores.
As I understand, these block IL-1beta, or interleukin-1 beta :
Curcumin
Quercetin
Fish oil
Genistein
EGCG
Resveratrol / pterostilbene
Ellagic acid
Ginger
Ursolic acid
Olive oil/extracts
Blueberries
Xanthohumol
White wine
Netltle leaf (urtica dioca)
Propentofylline
Pentoxifylline (Trental)
Thalidomide
Be aware, though, that pentoxifylline and thalidomide performed disappointingly in trials.
Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively
Improve the Performance and Attenuate the Symptoms Due to the
Motor Neuron Loss in ALS Disease
Patients with elevated triglyceride and cholesterol serum levels have a
prolonged survival in amyotrophic lateral sclerosis.
Patients with elevated triglyceride and - PubMed Mobile
Lower serum lipid levels are related to respiratory impairment in patients with ALS.
Lower serum lipid levels are related to - PubMed Mobile
Dyslipidemia is a protective factor in amyotrophic lateral sclerosis
Dyslipidemia is a protective factor in - PubMed Mobile