I find this discussion very interesting since I am contemplating my next move with my Lyme doc. My original diagnosis was bulbar ALS and it took 3 Lyme tests until I tested positive for Lyme with a special lab. The lab tests also revealed a strong coinfection of Toxoplasmosis. I had done months of IV antibiotics before the Lyme doc figured out that the Toxoplasmosis was inhibiting the Lyme treatment and that both infections needed to be treated together aggressively. The problem is that the antibiotics have definitely taken a toll on my body and left me significantly weaker. My breathing is being impacted because my diaphagm and chest is now weak. (FVC is 44) Proceeding with more antibiotics is becoming more risky but may also be my only hope. I do believe that once we started to treat both infections that slow progress has been made. The question is will I see an upside to the treatments before they render me so weak that I cannot breath without being on the bipap machine constantly? My wife thinks I'm crazy and chasing a pipe dream put into my head by the Lyme doc. I still believe there is a real chance. It's like rolling the dice for my life...do I feel lucky?