Connect with us:
Follow ALSforums on Twitter   Join us on Facebook   Subscribe to our RSS feed



   

Term: Wobbler



Name: Wobbler
Category: Research Terms
Actions: Update Term
Have a Wobbler resource to add?

Please e-mail us your “Wobbler” changes, additions, or website resource links to info(@)alsforums.com.

All additions are subject to review and approval.

Additions to this resource must be directly related to Wobbler.

Want to make an edit to this resource?

Edit this resource right now!
coming soon

Wobbler is a neurodegenerative disease model that arose in a laboratory mouse by chance. As it has a very valuable phenotype that mimics ALS and other motor neuron diseases, it was maintained by breeding. As it was a mutation that arose spontaneously, we currently have no information on where in the mouse genome the ALS-producing mutation is present. Currently investigators are trying to identify the location of the mutation in the mouse. Various therapies have been tested in this model and most of the drugs that worked in the model also worked in the genetic ALS model (SOD1G93A). Thus it appears that this is a good model for screening drugs.



     Site is Powered by PHP Site is Powered by MySQL    RSS Feed - ALS Support Group Forum   ALSforums - Get help and support with ALS/MND