|
|
|
|
Term: Wobbler
| Name: |
Wobbler |
| Category: |
Research Terms |
| Actions: |
Update Term |
|
Have a Wobbler resource to add?
Please e-mail us your “Wobbler” changes, additions, or website resource links to info(@)alsforums.com.
All additions are subject to review and approval.
Additions to this resource must be directly related to Wobbler.
Want to make an edit to this resource?
Edit this resource right now!
coming soon
|
Wobbler is a neurodegenerative disease model that arose in a laboratory mouse by chance. As it has a very valuable phenotype that mimics ALS and other motor neuron diseases, it was maintained by breeding. As it was a mutation that arose spontaneously, we currently have no information on where in the mouse genome the ALS-producing mutation is present. Currently investigators are trying to identify the location of the mutation in the mouse. Various therapies have been tested in this model and most of the drugs that worked in the model also worked in the genetic ALS model (SOD1G93A). Thus it appears that this is a good model for screening drugs.
|
|
|
