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ALS breakthrough could be seen with new Isis drug trialJuly 28, 2006
Isis drug researchers have designed and tested a new molecular theraphy in animals that they hope will soon be a major breakthrough for ALS patients.
Researchers from the University of California School of Medicine, at the Center for Neurologic Study, in combination with Isis Pharmaceuticals have completed a study that shows that therapeutic molecules known as antisense oligonucleotides can be delivered to the brain and spinal cord through the cerebrospinal fluid (CSF) at doses shown to slow the progression of amyotrophic lateral sclerosis.
The researchers found that, when effective doses of the antisense therapy were delivered through teh spinal cord that far less of the SOD1 protein that causes hereditary ALS were produced.
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